A landmark Cell Reports Medicine study analyzed the genome, epigenome, microbiome, and metabolome of Maria Branyas Morera, the world’s oldest verified person. The findings reveal that extreme longevity results from…
Clinical trials show that structured slow breathing at six breaths per minute activates the vagus nerve, raises heart rate variability, and shifts the autonomic nervous system toward parasympathetic dominance within…
Lipoprotein(a) is a genetically inherited cardiovascular risk factor that affects roughly one in five people worldwide and cannot be meaningfully lowered by statins, diet, or exercise. In 2026, a new…
ARPA-H’s $144 million PROSPR program is testing rapamycin, semaglutide, and dapagliflozin in 726 healthy older adults, funding a first-in-humans trial of a retrotransposon-silencing HIV drug, and building a validated biological…
A growing body of clinical evidence shows that resistance training reduces depression symptoms as effectively as frontline medications, slows cognitive decline in aging adults, and triggers neurobiological changes that no…
A Stanford Nature study shows gut bacteria drive age-related memory loss through vagus nerve inflammation, while new research in Nature Communications, npj Biofilms and Microbiomes, and Microbiology Spectrum reveals that…
A landmark UK Biobank study of 60,977 people found that sleep regularity is a stronger predictor of mortality than sleep duration, reducing all-cause death risk by 30 percent. Combined with…
David Sinclair helped make longevity science impossible to ignore. He also became one of its most contested public figures. Part II examines the criticism, contradictory evidence, and scientific arguments that…
The EVOKE and EVOKE+ trials of oral semaglutide in 3,808 Alzheimer’s patients failed their primary endpoints, but stunning biomarker data, positive liraglutide brain volume results, and consistent real-world evidence from…
David Sinclair helped move aging research from the scientific margins into mainstream conversation. Through his Harvard lab, his work on sirtuins, NAD+ biology, epigenetic reprogramming, and his public role as…
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