Function Health Membership: 100+ Biomarker Testing for Comprehensive Health Monitoring

The most expansive consumer blood testing platform available, measuring over 100 biomarkers twice per year with physician oversight, designed for people who want the closest thing to a clinical research panel without a research appointment.

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The average annual physical blood panel tests somewhere between 10 and 20 markers. A comprehensive metabolic panel, a lipid panel, maybe a CBC. These tests were designed for disease detection, not disease prevention. They catch problems after they have developed, not while they are developing. Yet the bloodstream carries measurable signals across dozens of systems simultaneously: cardiovascular, metabolic, hormonal, inflammatory, immune, hepatic, renal, nutritional, and oncologic. The gap between what medicine tests routinely and what science can measure routinely is where the next decade of preventive health innovation will play out. Function Health was built to close that gap, offering the broadest consumer blood biomarker panel available: over 100 markers, twice per year, for $499 annually.

What Is Function Health?

Function Health is an annual membership-based blood testing service that provides two comprehensive panels per year, each measuring over 100 biomarkers. The panel spans cardiovascular health (ApoB, Lp(a), homocysteine, advanced lipids), metabolic function (HbA1c, fasting insulin, glucose), hormones (testosterone, estradiol, DHEA-S, thyroid panel, cortisol), inflammation (hsCRP, ferritin), liver and kidney function, vitamins and minerals (vitamin D, B12, folate, iron, magnesium, zinc), cancer screening markers, and immune function indicators.

Members schedule blood draws at Labcorp locations nationwide. Results are delivered through Function Health’s digital platform with clear explanations, reference ranges, trend tracking across tests, and physician review. The platform categorizes each result as optimal, needs attention, or critical, providing a triaged overview that makes 100+ numbers manageable.

Function Health was co-founded by Dr. Mark Hyman, a prominent functional medicine physician, and Jonathan Swerdlin. The company has attracted significant venture capital and built a waitlist-based enrollment model that has generated substantial consumer interest. The $499 annual membership covers both semi-annual panels, with no additional per-test fees.

The Science Behind Comprehensive Biomarker Panels

The rationale for testing 100+ biomarkers rests on a systems biology perspective: the human body is not a collection of isolated organs but an interconnected network where dysfunction in one system creates ripple effects across others. Insulin resistance, for example, does not just elevate blood sugar. It increases triglycerides, lowers HDL, elevates hsCRP, disrupts hormonal balance, promotes hepatic fat accumulation, and accelerates vascular aging. A standard metabolic panel catches the glucose elevation but misses the cascade.

Lipoprotein(a), or Lp(a), illustrates the value of testing beyond standard panels. Lp(a) is genetically determined, affects approximately 20% of the population at elevated levels, and is an independent risk factor for heart attack and stroke. Yet it is almost never included in routine blood work. Most people discover their elevated Lp(a) only after a cardiovascular event, by which point atherosclerosis has been progressing for years or decades. Function Health includes Lp(a) in every panel.

Similarly, fasting insulin is a far earlier indicator of metabolic dysfunction than fasting glucose. Insulin levels rise years before glucose crosses diagnostic thresholds for prediabetes, because the pancreas compensates by producing more insulin to maintain glucose homeostasis. By the time glucose is elevated, the metabolic machinery has already been strained for years. Including fasting insulin in a routine panel catches the upstream problem, not the downstream symptom.

The Four Shadows identified in Healthcare Discovery‘s longevity framework, cardiovascular disease, cancer, neurodegenerative disease, and metabolic dysfunction, all leave detectable traces in the bloodstream long before clinical symptoms appear. ApoB and Lp(a) for cardiovascular risk, HbA1c and fasting insulin for metabolic dysfunction, inflammatory markers like hsCRP for cancer and neurodegeneration risk, and hormonal markers for systemic resilience: a 100+ marker panel provides visibility across all four threat categories simultaneously.

That is the science. Here is how Function Health applies it.

What Function Health Does Well

The sheer breadth of the panel is Function Health’s defining advantage. At over 100 biomarkers, it is the most comprehensive consumer blood test available, surpassing InsideTracker Ultimate (54 markers), Thorne Health Tests (approximately 30 markers), and most direct-access lab panels. Markers like Lp(a), homocysteine, fasting insulin, and a full thyroid panel (including free T3, free T4, and thyroid antibodies) are included as standard, not add-ons.

The semi-annual testing cadence builds in longitudinal tracking. A single blood test is a snapshot; two tests per year create a trajectory. Function Health’s platform displays trends across tests, making it easy to see whether interventions (dietary changes, new supplements, exercise modifications) are moving markers in the right direction. This trend visualization transforms raw numbers into a narrative about health trajectory.

Physician review adds a layer of clinical oversight that purely algorithmic platforms lack. While Function Health is not a replacement for a primary care relationship, having a licensed physician review 100+ markers and flag concerning patterns provides a safety net that self-service lab testing does not offer.

The pricing model is remarkably efficient. At $499 per year for two comprehensive panels, the per-marker cost is under $2.50. Ordering equivalent tests through Quest Diagnostics Direct or Labcorp OnDemand individually would cost several thousand dollars. Function Health’s wholesale lab relationship enables pricing that makes comprehensive testing economically accessible for the first time.

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Pricing, Access, and Practical Realities

Function Health costs $499 per year, which includes two comprehensive blood panels (typically spaced six months apart). There are no additional per-test fees, no subscription tiers, and no hidden costs beyond the annual membership. The first-year total cost of ownership is $499.

Blood draws are conducted at Labcorp locations nationwide, providing broad geographic access. Results are delivered through the Function Health digital platform, typically within one to two weeks of the blood draw.

Function Health uses CLIA-certified laboratories. The service operates under physician oversight, with a licensed physician reviewing results and flagging critical values. However, it is positioned as a wellness and preventive health service, not a clinical diagnostic tool. Members should share results with their primary care provider for clinical interpretation and treatment decisions.

The membership is HSA and FSA eligible, meaning the entire $499 annual cost can be paid with pre-tax health savings dollars. This effectively reduces the out-of-pocket cost by 20% to 35% depending on the member’s tax bracket.

Function Health has operated with a waitlist model, meaning enrollment may not be immediately available. Prospective members should check current availability on the company’s website.

Who Function Health Is Best For

Function Health is designed for health-conscious individuals who want the most comprehensive view of their internal health available without a clinical research enrollment. It suits people who believe in the preventive medicine philosophy that early detection through broad biomarker screening is superior to waiting for symptoms. Longevity-focused adults who want to monitor all four of the Four Shadows through a single blood draw. Anyone with a family history of cardiovascular disease, cancer, diabetes, or neurodegenerative conditions who wants proactive surveillance beyond what standard annual physicals provide.

The platform is particularly valuable for people who already work with functional medicine practitioners, naturopathic doctors, or longevity-focused physicians who know how to interpret comprehensive panels and translate results into clinical action plans.

People who should skip Function Health include those who want highly personalized AI-driven recommendations (InsideTracker’s recommendation engine is more sophisticated), anyone who finds 100+ results overwhelming without a practitioner to interpret them, individuals who need clinical-grade diagnostic testing under direct physician supervision, and those on tight budgets who would benefit more from targeted panels focused on their specific risk factors.

How Function Health Compares

Against InsideTracker Ultimate ($699 for 54 markers), Function Health offers nearly twice the biomarker count at a lower price, plus a second test included in the annual fee. InsideTracker counters with a more sophisticated recommendation engine, the InnerAge biological age algorithm, and integration with fitness trackers. The choice depends on whether you prioritize data breadth (Function Health) or actionable interpretation (InsideTracker).

Against SiPhox Health ($149 to $299 per panel), Function Health provides dramatically more biomarkers but at a higher annual cost and with the requirement of a lab visit rather than an at-home fingerstick. SiPhox is ideal for targeted cardiometabolic monitoring; Function Health is for comprehensive health surveillance.

Against direct-access lab services (Quest Direct, Labcorp OnDemand), Function Health offers a curated, comprehensive panel at a bundled price that would be difficult to replicate by ordering individual tests. The convenience of a single order for 100+ markers, with results organized on a purpose-built platform, adds meaningful value beyond the raw testing.

Limitations and Open Questions

The most significant limitation of Function Health is interpretive support. One hundred biomarkers produce a complex dataset that requires clinical expertise to interpret holistically. While the platform provides physician review and color-coded result categorization, the depth of interpretation does not match what a longevity-focused physician would provide in a one-on-one consultation. Members who do not have an existing relationship with a practitioner skilled in comprehensive biomarker interpretation may struggle to translate results into action.

The semi-annual testing cadence, while useful for trend tracking, may not be frequent enough for individuals making aggressive lifestyle changes who want shorter feedback loops. Some markers (like LDL and triglycerides) can change within weeks of dietary modifications, and waiting six months for the next test may feel too long.

Function Health’s waitlist model creates uncertainty about enrollment timing. Prospective members may need to wait weeks or months to begin testing, which can be frustrating for people motivated to start immediately.

As with all consumer blood testing, results reflect a single point in time and can be affected by acute factors: recent exercise, alcohol, sleep quality, hydration, illness, and medications all influence biomarker levels. Testing under standardized conditions (fasted, rested, well-hydrated) improves reliability but cannot eliminate all sources of variability.

What This Means for Your Health

Function Health represents the most comprehensive attempt yet to bring research-grade blood testing to a consumer audience at an accessible price point. For $499 per year, members get visibility into cardiovascular risk (ApoB, Lp(a), homocysteine), metabolic health (fasting insulin, HbA1c), hormonal balance, inflammatory status, nutritional sufficiency, and organ function. This is the kind of comprehensive screening that was previously available only to participants in longitudinal research studies or patients of concierge medicine practices charging $5,000+ annually.

Within HealthcareDiscovery.ai’s Five Pillars framework, a 100+ biomarker panel reflects the impact of every pillar simultaneously. Nutrition shows up in glucose, insulin, lipids, and vitamin levels. Sleep appears in cortisol, inflammatory markers, and hormonal balance. Movement influences lipids, glucose regulation, inflammatory markers, and cardiovascular markers. Breathwork and stress management appear in cortisol and inflammatory cascades. Mindset and social connection, while harder to measure directly, influence hormonal and immune function that the panel captures.

The longevity thesis is simple: the Four Shadows (cardiovascular disease, cancer, neurodegenerative disease, and metabolic dysfunction) do not arrive without warning. They develop over years and decades, leaving biochemical footprints in the blood long before they produce symptoms. A comprehensive panel, repeated semi-annually, is the closest thing available to an early warning system for the diseases that end healthspan. Function Health makes that system available to anyone willing to invest $499 per year and a lab visit every six months.

Frequently Asked Questions

How many biomarkers does Function Health test?
Function Health tests over 100 biomarkers per panel, making it the most comprehensive consumer blood test available. The panel includes cardiovascular markers (ApoB, Lp(a), homocysteine, advanced lipids), metabolic markers (HbA1c, fasting insulin, glucose), hormones (testosterone, estradiol, DHEA-S, full thyroid panel, cortisol), inflammation markers (hsCRP, ferritin), vitamins and minerals, liver and kidney function, and cancer screening markers.

How much does Function Health cost?
Function Health costs $499 per year, which includes two comprehensive blood panels (typically six months apart). There are no additional per-test fees. The membership is HSA and FSA eligible. At over 100 markers per panel, the per-marker cost is under $2.50, making it the most cost-effective comprehensive blood testing option available to consumers.

How is Function Health different from InsideTracker?
Function Health tests 100+ biomarkers (vs. InsideTracker Ultimate’s 54) at a lower annual cost ($499 vs. $699 per test). However, InsideTracker offers a more sophisticated AI-powered recommendation engine, the InnerAge biological age algorithm, and integration with fitness wearables. Function Health prioritizes data breadth and physician review; InsideTracker prioritizes actionable interpretation and personalized recommendations.

Do I need a doctor to use Function Health?
No prescription is needed to enroll. Function Health operates under physician oversight, with a licensed physician reviewing all results. However, the platform is a wellness service, not a clinical diagnostic tool. Members are encouraged to share results with their primary care provider, especially if any markers fall outside normal ranges or if they are managing existing health conditions.

How often does Function Health test?
The annual membership includes two comprehensive panels per year, typically spaced six months apart. This semi-annual cadence allows for trend tracking and provides enough time for lifestyle interventions to produce measurable changes in most biomarkers. Members who want more frequent testing would need to supplement with additional services.

What is Lp(a) and why does Function Health include it?
Lipoprotein(a), or Lp(a), is a genetically determined lipoprotein that is an independent risk factor for heart attack and stroke. Approximately 20% of the population has elevated Lp(a) levels, but it is almost never tested in routine blood work. Unlike LDL cholesterol, Lp(a) does not respond significantly to diet or statins. Knowing your Lp(a) level helps you and your physician assess your true cardiovascular risk and consider appropriate interventions. Function Health includes Lp(a) in every panel.

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