Beyond Inheritance by Roxanne Khamsi: A Review
An inaugural entry in HD Reads. Roxanne Khamsi’s Beyond Inheritance is the most important popular biology book of 2026 to date, and the foundation text for a way of seeing…
Clonal Hematopoiesis (CHIP): The Cardiovascular Risk Hidden in Your Blood
By age seventy, somewhere between ten and twenty percent of people carry a population of mutated blood stem cells that quietly double their risk of heart disease. The condition has…
Mosaic Aging: Why Your Organs Age at Different Rates, and Why It Matters
A growing body of work argues that the body does not age all at once. It ages in tiles. The pace at which your fastest-aging organ breaks down, not the…
The Hashimoto’s Breakthrough: Somatic Mutations and the New Model of Autoimmune Disease
A landmark Nature study finds that Hashimoto’s thyroiditis is driven in part by acquired somatic mutations that disable the immune system’s brakes. A new model of autoimmune disease is taking…
The Mosaic Body: How Your Cells Are Quietly Mutating, and Why It’s Rewriting Medicine
A new picture of the human body is emerging from the world’s genome sequencers, and it is not the one most of us were taught. We are not single, settled…
Cyclic Sighing: The Five Minute Breathwork Protocol That Outperformed Meditation in a Stanford Trial
A 2023 Stanford randomized trial found that five minutes a day of cyclic sighing produced larger gains in mood, anxiety, and respiratory rate than mindfulness meditation. Inside the vagus nerve…
Lipoprotein(a): The Hidden Genetic Heart Risk Finally Becoming Treatable in 2026
Lp(a) affects one in five adults worldwide yet has had no targeted therapy for sixty years. In 2026, four Phase 3 trials including HORIZON, OCEAN(a)-Outcomes, ACCLAIM-Lp(a), and a new oral…
The First Longevity Board: How Insilico Medicine Is Using AI to Target the Biology of Aging Itself
Insilico Medicine has formed the industry’s first Longevity Board, chaired by Eli Lilly’s Group VP of Molecular Discovery and featuring Nobel laureate Michael Levitt. Inside the AI strategy, dual-purpose targets,…
The Daily Rounds: Longevity & Health Care Brief | April 24, 2026
🧬 SuperAgers Grow Twice as Many New Neurons — Adults over 80 with 50-year-old-level memory generate up to 2.5 times more new neurons than peers, redefining what is biologically possible for the aging brain. 🤖 AI Drug Discovery Reaches Scale — Novo Nordisk joins OpenAI while NVIDIA commits $1 billion alongside Lilly, as 173-plus AI-discovered drug programs advance through clinical trials simultaneously. ⌚ Wearables Achieve Clinical-Grade Metabolic Prediction — The WEAR-ME study confirms consumer wearables predict insulin resistance with 80% accuracy, enabling population-scale metabolic screening without lab visits. 🌙 Circadian-Aligned Eating Extends Lifespan by 35% — A Science study shows that timing meals within the optimal circadian window delivers lifespan gains far beyond caloric restriction alone. 💪 Muscle Mass Is Metabolic Medicine — Every 10% gain in muscle mass reduces insulin resistance by 11%, with men who skip strength training 2.4 times more likely to develop metabolic disease.
Zone 2 Training: The Mitochondrial Science Behind Low-Intensity Cardio and Why It Matters for Longevity
Zone 2 training has become the most talked about protocol in longevity circles, from Peter Attia to Iñigo San-Millán. Here is what the mitochondrial science actually says about low-intensity cardio,…
