First documented by Makoto Kuro-o in a 1997 Nature paper, the Klotho hormone has spent thirty years quietly accumulating one of the deepest evidence bases in aging biology. With Phase…
Iñigo San Millán’s mitochondrial research, Peter Attia’s popularization, and Stephen Seiler’s polarized training data have converged into a new consensus: the easy, conversational pace most people skip may be the…
University of Rochester researchers transferred the naked mole rat’s longevity gene, nmrHAS2, into mice and produced animals with 34% less cancer, lower inflammaging markers, healthier guts, and a 4.4% longer…
A proteomics study tracking 3,000 proteins during a seven-day water-only fast found that the body’s most dramatic biological changes do not appear until 72 hours in. The implications are reshaping…
A casual conversation between two Mayo Clinic graduate students sparked a discovery that could solve one of longevity medicine’s most stubborn problems: finding the cells that silently drive aging, cancer,…
Researchers at the University of Minnesota have identified naturally occurring fatty acids, specifically alpha-eleostearic acid and its methyl ester derivative, that selectively kill senescent zombie cells through ferroptosis. Published in…
The wellness industry is selling NAD+ pills and IV infusions as longevity interventions. On May 11, 2026, NPR asked what the science actually shows. We went deeper: tracing the biology,…
Two landmark studies published in Nature used AI-powered deep learning to show that thymic health predicts longevity, cardiovascular risk, and cancer immunotherapy outcomes, rewriting decades of assumptions about adult biology…
For decades, neuroscience taught that the adult human brain was a closed shop: every neuron you would ever own was already wired by the time you finished puberty. A wave…
Spermidine triggers autophagy, the cell’s recycling system, and a 20 year Austrian cohort linked higher dietary intake to roughly 5 fewer years of mortality. Inside the Frank Madeo Graz research,…
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