A landmark 2026 study in Nature Aging reveals that phosphoenolpyruvate (PEP), a glycolytic metabolite, acts as a natural brake on the cGAS-STING inflammatory pathway. As PEP levels decline with age, chronic inflammaging accelerates — and restoring PEP in animal models delays aging phenotypes and improves cognition.
A cluster of landmark studies is forcing scientists to ask a radical question: could the drugs that conquered obesity also slow the biological clock? The answer is more complicated, and more important, than the headlines suggest. For most of their clinical history, GLP-1 receptor agonists were diabetes drugs. Then they became weight loss blockbusters. Now,…
A landmark 2021 Stanford study found that a diet rich in fermented foods increased gut microbiome diversity and lowered 19 inflammatory proteins, while a high fiber diet did not. Here is what the science shows, how it connects to the four fundamentals of nutrition, breath, sleep, and movement, and what you can do starting with your next meal.
A single handheld meter that measures five biomarkers from a fingerstick: blood glucose, blood ketones, uric acid, hemoglobin, and hematocrit, making it the most versatile point-of-care device available to consumers. Uric acid is one of the most underappreciated biomarkers in metabolic health. Best known as the molecule that causes gout when it crystallizes in joints,…
A widely available at-home blood and urine testing platform that puts basic metabolic screening in reach for anyone who wants to check their HbA1c, cholesterol, thyroid, and cortisol without a doctor’s visit. Nearly 40% of American adults have prediabetes. Of those, more than 80% do not know it. The condition is clinically silent: no symptoms,…
The most expansive consumer blood testing platform available, measuring over 100 biomarkers twice per year with physician oversight, designed for people who want the closest thing to a clinical research panel without a research appointment. The average annual physical blood panel tests somewhere between 10 and 20 markers. A comprehensive metabolic panel, a lipid panel,…
A microfluidics-powered fingerstick blood panel that brings advanced cardiometabolic markers like ApoB, hsCRP, and HbA1c to your kitchen table at a fraction of the cost of traditional lab panels. Apolipoprotein B (ApoB) is arguably the single most important blood marker for cardiovascular risk that most people have never heard of. Unlike LDL cholesterol, which measures…
The most comprehensive consumer blood biomarker panel available, measuring 54 markers across metabolic, hormonal, inflammatory, and cardiovascular categories, with AI-powered recommendations and biological age calculation. The standard annual physical captures a handful of blood markers: fasting glucose, a basic lipid panel, maybe a complete blood count. For most people, that snapshot is the only window…
A portable indirect calorimetry system that brings VO2max testing and resting metabolic rate measurement out of the research lab and into the gym, the wellness clinic, and the coaching studio. Each unit increase in maximal oxygen consumption (VO2max) is associated with a 45-day increase in life expectancy. That finding comes from a landmark 2018 study…
A handheld device that measures your breath CO2 concentration to determine whether your body is burning fat or carbohydrates, turning the concept of metabolic flexibility from a laboratory metric into a daily habit. Metabolic flexibility is the body’s ability to switch efficiently between burning carbohydrates and burning fat depending on fuel availability, activity demands, and…
Zach RobertsSign up for personalized wellness coaching and the Daily Discovery Newsletter.