☕ Coffee and the Gut-Brain Axis — A Nature Communications study of 62 adults found both caffeinated and decaf coffee reshape gut microbiome composition in ways tied to better mood, memory, and stress resilience. 🏆 Bowel Cancer Trial: Zero Relapses at 33 Months — The NEOPRISM-CRC trial found nine weeks of pre-surgical pembrolizumab kept 100% of MMR-deficient colorectal cancer patients relapse-free well past the three-year mark. ⌚ Wrist Wearables Now Measure Biological Age — PpgAge, built from 213,000 Apple Study participants, predicts heart disease and diabetes onset from a wristwatch sensor, pushing consumer health into clinical biomarker territory. 💊 AI Drug Discovery Reaches Phase I — XtalPi's AI-discovered PRMT5 inhibitor PEP08 enrolled its first patients in a Phase I solid tumor trial, adding to 173 AI-discovered compounds now in human trials globally. 🏋️ GLP-1 and Muscle Loss Demand Clinical Action — Up to 40% of weight lost on GLP-1 drugs is lean muscle, and a JAMA perspective argues structured exercise must be co-prescribed as a clinical standard, not a lifestyle afterthought.